Browsing Experimentally Confirmed database

Result: Your query found 97 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
acrD
  • BacMet ID: BAC0563
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn)
  • Description: Acriflavine resistance protein D; participates in the efflux of aminoglycosides. It confers resistance to a variety of these substances. It contributes to copper and zinc resistance in Salmonella.
  • Length (amino acid): 1037
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    actA
  • BacMet ID: BAC0567
  • Code for: Enzyme
  • Family: CN hydrolase family. Apolipoprotein N-acyltransferase subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti TG2-6
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid]
  • Description: Apolipoprotein N-acyltransferase. Transfers the fatty acyl group on membrane lipoproteins. It has an essential role in acid tolerance of Rhizobium meliloti.
  • Length (amino acid): 531
  • Reference: Tiwari et al. 1996; Pubmed- 8868435, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actP
  • BacMet ID: BAC0012
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
  • Location: Plasmid pSMED01 (Sinorhizobium medicae (strain WSM419))
  • Compound: Copper (Cu), Sodium acetate [class: Acetate]
  • Description: Copper-transporting P-type ATPase; Involved in copper efflux; Transcriptionally regulated by HmrR in response to Cu+ ions.
  • Length (amino acid): 827
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actP
  • BacMet ID: BAC0568
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-transporting P-type ATPase. Involved in copper efflux. Transcriptionally regulated by HmrR in response to Cu+ ions.
  • Length (amino acid): 841
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    baeR
  • BacMet ID: BAC0596
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 240
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

    		• Similar resistance genes in 'BacMet Predicted database'
    baeS
  • BacMet ID: BAC0597
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 467
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

    		• Similar resistance genes in 'BacMet Predicted database'
    bhsA/ycfR/comC
  • BacMet ID: BAC0049
  • Code for: Regulator
  • Family: BhsA/McbA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction
  • Length (amino acid): 85
  • Reference: Zhang et al. 2007; Pubmed- 17293424, Mermod et al. 2012; Pubmed- 22089859

    		• Similar resistance genes in 'BacMet Predicted database'
    cinA
  • BacMet ID: BAC0067
  • Code for: unknown
  • Family: Azurin-plastocyanin family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa PAO1
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-containing azurin-like protein cinA; CinA is similar to the P. fluorescens DF57 Cot protein which is involved in copper tolerance; cinA Influences the ability of Pseudomonas aeruginosa PAO1 to resist the bactericidal effect of copper
  • Length (amino acid): 205
  • Reference: Elquindi et al. 2009; Pubmed- 19239551, Quaranta et al. 2007; Pubmed- 17483220

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeA
  • BacMet ID: BAC0068
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: RND efflux system, a periplasmic fusion protein CmeA. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 367
  • Reference: Lin et al. 2002; Pubmed- 12069964

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeB
  • BacMet ID: BAC0613
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Acridine orange [class: Acridine]
  • Description: An inner membrane efflux transporter. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 1040
  • Reference: Lin et al. 2002; Pubmed- 12069965, Pumbwe et al. 2004; Pubmed- 15201231

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeC
  • BacMet ID: BAC0614
  • Code for: Efflux
  • Family: RND superfamily, OMF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: An outer membrane protein (CmeC). Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 492
  • Reference: Lin et al. 2002; Pubmed- 12069966

    		• Similar resistance genes in 'BacMet Predicted database'
    comR/ycfQ
  • BacMet ID: BAC0076
  • Code for: Regulator
  • Family: TetR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.
  • Length (amino acid): 210
  • Reference: Deng et al. 2011; Pubmed- 21498759

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0077
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pRJ1004 (E. coli)
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Encode for copper uptake ATPases; also resistant to Ag+ ; periplasmic protein; Probably involved in copper and silver Export. Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity.
  • Length (amino acid): 609
  • Reference: Cha and Cooksey 1991; Pubmed- 1924351, Outten et al. 2001; Pubmed- 11399769

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0078
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in copper export; The copZA operon is activated by CueR and indirectly repressed by YfmP
  • Length (amino acid): 802
  • Reference: Banci et al. 2003; Pubmed- 14514665, Outten et al. 2001; Pubmed- 11399769

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0619
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida PNL-MK25
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Part of copABCD operon, that encodes copper-binding and sequestering proteins for copper homeostasis in the copper-sensitive strain Pseudomonas putida PNL-MK25.
  • Length (amino acid): 564
  • Reference: Adaikkalam et al. 2005; Pubmed- 15920618

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0620
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Probably involved in copper import under copper limiting conditions.
  • Length (amino acid): 727
  • Reference: Odermatt et al. 1994; Pubmed- 8037745, Solioz et al. 1995; Pubmed- 7721839

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0621
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas citri subsp. Citri
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein A.
  • Length (amino acid): 623
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0622
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Involved in copper and silver export.
  • Length (amino acid): 804
  • Reference: Mandal et al. 2002; Pubmed- 11756450

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0623
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Probably involved in copper export. Part of copAP operons of Helicobacter pylori and Helicobacter felis.
  • Length (amino acid): 741
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0624
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-transporting ATPase. part of copAP operon.
  • Length (amino acid): 732
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0625
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas alfalfae subsp. Citrumelonis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein A. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 622
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0626
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D
  • Compound: Copper (Cu)
  • Description: Copper resistance protein B. It mediates copper resistance by its sequestration in the outer membrane. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 328
  • Reference: Mellano et al. 1988; Pubmed- 3372485, Cha et al. 1991; Pubmed- 1924351

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0627
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas alfalfae subsp. Citrumelonis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein B.
  • Length (amino acid): 422
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0628
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas citri subsp. Citri
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein B. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 422
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0629
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: It is a thermophilic Cu2+-ATPase in Archaeoglobus fulgidus. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 690
  • Reference: Mana-Capelli et al. 2003; Pubmed- 12876283,

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0079
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Efflux ATPases, located in same operone with copA; outer membrane protein, have 4 impefect repeats of octapeptide Asp-His-Ser-Gln/Lys-Met-Gln-Met; Required for the copper-inducible Expression of copper resistance. It is a pump for the extrusion of monovalent copper and silver ions, with copper probably being the natural substrate.
  • Length (amino acid): 745
  • Reference: Odermatt et al. 1994; Pubmed- 8037745, Solioz et al. 1995; Pubmed- 7721839

    		• Similar resistance genes in 'BacMet Predicted database'
    copC
  • BacMet ID: BAC0630
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D
  • Compound: Copper (Cu)
  • Description: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopA. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 126
  • Reference: Cha et al. 1991; Pubmed- 1924351

    		• Similar resistance genes in 'BacMet Predicted database'
    copC
  • BacMet ID: BAC0631
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas citri subsp. Citri
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein C.
  • Length (amino acid): 127
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copC
  • BacMet ID: BAC0639
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion binding protein copC. Part of the copRSCD cluster required for full copper resistance and regulated at the transcription level by Cu in Pseudomonas fluorescens. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens.
  • Length (amino acid): 127
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copD
  • BacMet ID: BAC0632
  • Code for: Membrane Transporter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D
  • Compound: Copper (Cu)
  • Description: Involved in copper resistance. Appears to be involved in copper uptake in conjunction with CopC. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 310
  • Reference: Mellano et al. 1988; Pubmed- 3372485, Bender et al. 1987; Pubmed- 3027030

    		• Similar resistance genes in 'BacMet Predicted database'
    copD
  • BacMet ID: BAC0633
  • Code for: Membrane Transporter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida PNL-MK25
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein D; Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 291
  • Reference: Adaikkalam et al. 2005; Pubmed- 15920618

    		• Similar resistance genes in 'BacMet Predicted database'
    copD
  • BacMet ID: BAC0640
  • Code for: Membrane transpoter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Part of the copRSCD cluster required for full copper resistance and regulated at the transcription level by Cu in Pseudomonas fluorescens. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens.
  • Length (amino acid): 312
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copJ
  • BacMet ID: BAC0080
  • Code for: Enzyme
  • Family: Cytochrome C family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Copper (Cu)
  • Description: CopJ cytochrome c protein involved in Cu(II)/Cu(I) resistance; Structural genes like copA and copB; periplasmic protein; Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopA
  • Length (amino acid): 174
  • Reference: Cha et al. 1991; Pubmed- 1924351

    		• Similar resistance genes in 'BacMet Predicted database'
    copK
  • BacMet ID: BAC0081
  • Code for: Binding protein
  • Family: CopK family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) )
  • Compound: Copper (Cu)
  • Description: Copper resistance protein K; Involved in resistance to copper. Can bind up to 2 copper ions. Has higher affinity for Cu+ than for Cu2+
  • Length (amino acid): 94
  • Reference: Bersch et al 2008; Pubmed- 18533181

    		• Similar resistance genes in 'BacMet Predicted database'
    copL
  • BacMet ID: BAC0082
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas perforans
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in resistance to copper. Can bind up to 2 copper ions. Has higher affinity for Cu+ than for Cu2+.
  • Length (amino acid): 122
  • Reference: Behlau et al. 2011; Pubmed- 21515725, Voloudakis et al. 2005; Pubmed- 15691931

    		• Similar resistance genes in 'BacMet Predicted database'
    copP
  • BacMet ID: BAC0634
  • Code for: Binding protein
  • Family: Contains Heavy-metal-associated (HMA) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the cells.
  • Length (amino acid): 66
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copP
  • BacMet ID: BAC0635
  • Code for: Binding protein
  • Family: Contains Heavy-metal-associated (HMA) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the H. pylori cells.
  • Length (amino acid): 66
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copR
  • BacMet ID: BAC0083
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pPaCu1 (Pseudomonas syringae)
  • Compound: Copper (Cu)
  • Description: Transcriptional activator protein CopR; Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce Expression of the cop operon by binding to a specific site on the cop operon promoter (cop box) and possibly by facilitating the binding of RNA polymerase to the cop promoter. CopR also binds to the chromosomally encoded cop operon promoter. May also be involved in basic copper metabolism.
  • Length (amino acid): 227
  • Reference: Mills et al. 1993; Pubmed- 8449873

    		• Similar resistance genes in 'BacMet Predicted database'
    copR
  • BacMet ID: BAC0638
  • Code for: Regulator
  • Family: Contains response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Member of the two-component regulatory system CopS/CopR. May also be involved in basic copper metabolism. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens.
  • Length (amino acid): 231
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copS
  • BacMet ID: BAC0637
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Member of the two-component regulatory system CopS/CopR. May also be involved in basic copper metabolism.
  • Length (amino acid): 462
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copS
  • BacMet ID: BAC0537
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae
  • Location: Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pPaCu1 (Pseudomonas syringae)
  • Compound: Copper (Cu)
  • Description: Sensor protein CopS. Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cytoplasm. CopS/CopR may also regulate chromosomally encoded genes. May also be involved in basic copper metabolism.
  • Length (amino acid): 487
  • Reference: Mills et al. 1993; Pubmed- 8449873

    		• Similar resistance genes in 'BacMet Predicted database'
    copY/tcrY
  • BacMet ID: BAC0084
  • Code for: Regulator
  • Family: BlaI transcriptional regulatory family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: CopA and CopB upstream repressor CopY, regulates the cop operon; Binds to DNA in complex with Zn2+, repressing the transcription of the CopYZAB operon. Exchange of the bound zinc by two copper ions delivered by CopZ Cu1+-bound form causes release of CopY from the promoter, leading to the transcription of the operon
  • Length (amino acid): 145
  • Reference: Strusak et al. 1997; Pubmed- 9083014, Wunderli-Ye et al. 1999; Pubmed- 10362527

    		• Similar resistance genes in 'BacMet Predicted database'
    copZ
  • BacMet ID: BAC0085
  • Code for: Chaperone
  • Family: HMA (Heavy metal Associated) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper chaperone CopZ; copA and copB anti-repressor, regulates the cop operon
  • Length (amino acid): 69
  • Reference: Cobine et al. 1999; Pubmed- 10069368

    		• Similar resistance genes in 'BacMet Predicted database'
    corR
  • BacMet ID: BAC0089
  • Code for: Regulator
  • Family: Contains 1 sigma-54 factor interaction domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Myxococcus xanthus (strain DK 1622)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Sigma-54 dependent DNA-binding response regulator CorR; corSR copper-responsive two component system that induces carotenoid production. It also regulates three multicopper oxidases: cuoA, cuoB, cuoC, and two P-type ATPases: copA and copB.
  • Length (amino acid): 466
  • Reference: Sanchez-Sutil et al. 2013; Pubmed- 23874560

    		• Similar resistance genes in 'BacMet Predicted database'
    corS
  • BacMet ID: BAC0091
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Myxococcus xanthus (strain DK 1622)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Sensor histidine kinase CorS; corSR copper-responsive two component system that induces carotenoid production. It also regulates three multicopper oxidases: cuoA, cuoB, cuoC, and two P-type ATPases: copA and copB.
  • Length (amino acid): 491
  • Reference: Sanchez-Sutil et al. 2013; Pubmed- 23874560

    		• Similar resistance genes in 'BacMet Predicted database'
    crdA
  • BacMet ID: BAC0093
  • Code for: Efflux
  • Family: Contains a YtkA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance determinant, CrdA. It is required for adaptation to copper-rich environmental conditions.
  • Length (amino acid): 125
  • Reference: Waidner et al. 2002; Pubmed- 12426358

    		• Similar resistance genes in 'BacMet Predicted database'
    crdB
  • BacMet ID: BAC0094
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Putative copper resistance determinant, CrdC. It is required for adaptation to copper-rich environmental conditions.
  • Length (amino acid): 412
  • Reference: Waidner et al. 2002; Pubmed- 12426358

    		• Similar resistance genes in 'BacMet Predicted database'
    crdR
  • BacMet ID: BAC0095
  • Code for: Regulator
  • Family: Contains 1 Response_reg domain, 1 Trans_reg_C domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Response regulator; part of two-component regulatory system crdR/crdS
  • Length (amino acid): 213
  • Reference: Waidner et al. 2005; Pubmed- 15968080

    		• Similar resistance genes in 'BacMet Predicted database'
    crdS
  • BacMet ID: BAC0096
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Histidine kinase sensor protein; part of two-component regulatory system crdR/crdS
  • Length (amino acid): 397
  • Reference: Waidner et al. 2005; Pubmed- 15968080

    		• Similar resistance genes in 'BacMet Predicted database'
    csoR
  • BacMet ID: BAC0558
  • Code for: Regulator
  • Family: CsoR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis 168
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-sensing transcriptional repressor CsoR. Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu1+, which significantly decreases its DNA binding affinity and leads to the transcription of the genes. Cells lacking this gene display a slightly enhanced ability to grow into medium containing high levels of copper.
  • Length (amino acid): 101
  • Reference: Chillappagari et al. 2009; Pubmed- 19168619

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpG
  • BacMet ID: BAC0100
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Cation-transporting ATPase G; Response to copper ion
  • Length (amino acid): 771
  • Reference: Liu et al. 2007; Pubmed- 17143269, Sakamoto et al. 2010; Pubmed- 20395270

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpV
  • BacMet ID: BAC0101
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-exporting P-type ATPase V; Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence.
  • Length (amino acid): 770
  • Reference: Ward et al. 2010; Pubmed- 20624225

    		• Similar resistance genes in 'BacMet Predicted database'
    cueA
  • BacMet ID: BAC0102
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Copper transporter CueA; Periplasmic protein
  • Length (amino acid): 797
  • Reference: Adaikkalam et al. 2002; Pubmed- 12213931

    		• Similar resistance genes in 'BacMet Predicted database'
    cueO
  • BacMet ID: BAC0103
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper efflux oxidase (blue copper oxidase); Involved in periplasmic detoxification of copper by oxidizing Cu+ to Cu2+ and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm.
  • Length (amino acid): 516
  • Reference: Grass et al. 2001; Pubmed- 11222619, Outten et al. 2001; Pubmed- 11399769

    		• Similar resistance genes in 'BacMet Predicted database'
    cueP
  • BacMet ID: BAC0104
  • Code for: Binding protein
  • Family: unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Periplasmic copper-binding protein and has been implicated in the transfer of copper ions to SodCII in the periplasm; evolved to survive in the phagosomes of macrophages in Salmonella enterica serovar Typhimurium; CueP can functionally replace the Cus complex for periplasmic copper resistance, in particular under anaerobic conditions; CueP does not confer silver or gold resistance to Salmonella
  • Length (amino acid): 179
  • Reference: Pontel et al. 2009; Pubmed- 19538445, Osman et al. 2010; Pubmed- 20534583

    		• Similar resistance genes in 'BacMet Predicted database'
    cueR/ybbI
  • BacMet ID: BAC0105
  • Code for: Regulator
  • Family: MerR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. CueR is a direct regulator of copZA transcription that mediates copper induction
  • Length (amino acid): 135
  • Reference: Stoyanov et al. 2001; Pubmed- 11136469, Gaballa et al. 2003; Pubmed- 14663075

    		• Similar resistance genes in 'BacMet Predicted database'
    cuiD
  • BacMet ID: BAC0106
  • Code for: Enzyme
  • Family: Multicopper oxidase (MCO) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: A multi-copper oxidase gene code for Cu-inducible periplasmic protein; CuiD is required for both copper homeostasis and the copper resistance response in the presence and in the absence of oxygen; Probably involved in periplasmic detoxification of copper by oxidizing Cu+ to Cu2+ and thus preventing its uptake into the cytoplasm; cuiD may be involved in oxidative stress response
  • Length (amino acid): 536
  • Reference: Lim et al 2002; Pubmed- 12442888

    		• Similar resistance genes in 'BacMet Predicted database'
    cusA/ybdE
  • BacMet ID: BAC0107
  • Code for: Efflux
  • Family: RND superfamily; AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; located in cell inner membrane; Belongs to the AcrB/AcrD/AcrF family
  • Length (amino acid): 1047
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusB
  • BacMet ID: BAC0108
  • Code for: Efflux
  • Family: Membrane fusion protein(MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; Belongs to the membrane fusion protein (MFP) family
  • Length (amino acid): 407
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusC/ylcB
  • BacMet ID: BAC0109
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839))
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver
  • Length (amino acid): 457
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusF/cusX
  • BacMet ID: BAC0110
  • Code for: Efflux
  • Family: Contains 1 CusF_Ec domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pkPN3 (Klebsiella pneumoniae subsp. pneumoniae MGH 78578), Plasmid pAPEC-O2-R
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Cation efflux system periplasmic protein CusF; Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver. Binds one copper per polypeptide ; located in Periplasm
  • Length (amino acid): 110
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusR/ylcA
  • BacMet ID: BAC0111
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pECL_A (Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56))
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Member of the two-component regulatory system CusS/CusR. Activates the Expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level Expression of copper resistance gene operon pcoABCD; located in cytoplasm
  • Length (amino acid): 227
  • Reference: Munson et al. 2000; Pubmed- 11004187

    		• Similar resistance genes in 'BacMet Predicted database'
    cusS
  • BacMet ID: BAC0112
  • Code for: Regulator
  • Family: Contains 1 HAMP domain and 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Sensor kinase CusS; Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation; located in inner cell membrane
  • Length (amino acid): 480
  • Reference: Munson et al. 2000; Pubmed- 11004187

    		• Similar resistance genes in 'BacMet Predicted database'
    cutA
  • BacMet ID: BAC0113
  • Code for: Binding protein
  • Family: CutA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Divalent-cation tolerance protein CutA; Involved in resistance toward heavy metals
  • Length (amino acid): 112
  • Reference: Fong et al. 1995; Pubmed- 7623666

    		• Similar resistance genes in 'BacMet Predicted database'
    cutC
  • BacMet ID: BAC0114
  • Code for: Binding protein
  • Family: CutC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper homeostasis protein CutC; Involved in copper homeostasis; Located in cytoplasm
  • Length (amino acid): 248
  • Reference: Gupta et al. 1995; Pubmed- 7635807

    		• Similar resistance genes in 'BacMet Predicted database'
    cutE/lnt
  • BacMet ID: BAC0115
  • Code for: Enzyme
  • Family: CN hydrolase (Apolipoprotein N-acyltransferase subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Apolipoprotein N-acyltransferas, it attaches a fatty acid to apo-nlpE (cutF)
  • Length (amino acid): 512
  • Reference: Rogers et al. 1991; Pubmed- 1938881

    		• Similar resistance genes in 'BacMet Predicted database'
    cutF/nlpE
  • BacMet ID: BAC0116
  • Code for: Outer membrane lipoprotein
  • Family: Contains 1 NlpE domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper homeostasis protein CutF, encodes for outer membrane lipoprotein might affect on copper permeability; Involved in copper homeostasis. Could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. When overproduced induces degP through the activation of the two-component system CpxA/CpxR
  • Length (amino acid): 236
  • Reference: Gupta et al. 1995; Pubmed- 7635807

    		• Similar resistance genes in 'BacMet Predicted database'
    cutO
  • BacMet ID: BAC0117
  • Code for: Enzyme
  • Family: Multocopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacter capsulatus
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Multi copper oxidase CutO; Involved in copper resistance; CutO confers copper tolerance not only under aerobic conditions, as described for the well-characterized E. coli multicopper oxidase CueO, but also under anaerobic conditions.
  • Length (amino acid): 491
  • Reference: Wiethaus et al. 2006; Pubmed- 16487321

    		• Similar resistance genes in 'BacMet Predicted database'
    cutR
  • BacMet ID: BAC0118
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: CutR acts as a repressor of cutO Expression under low copper concentrations; Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism.
  • Length (amino acid): 118
  • Reference: Wiethaus et al. 2006; Pubmed- 16487321

    		• Similar resistance genes in 'BacMet Predicted database'
    dnaK
  • BacMet ID: BAC0133
  • Code for: Chaperone
  • Family: Heat shock protein 70 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Chaperone protein DnaK
  • Length (amino acid): 625
  • Reference: Graubner et al. 2007; Pubmed- 17215254

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbC
  • BacMet ID: BAC0138
  • Code for: Enzyme
  • Family: Thioredoxin family. DsbC subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Disulfide isomerase; DsbC rearranges incorrect disulfide bonds formed by dsbA during oxidative protein folding under non-stress conditions. DsbC, a periplasmic thiol-disulfide oxidoreductase, appears to function as a disulfide isomerase both in vitro and in vivo. In vitro, DsbC has been shown to rearrange non-native disulfides in well studied isomerization substrates such as BPTI and RNase A. In vivo, DsbC is required for full activity of a handful of proteins containing at least one non-consecutive disulfide bond.
  • Length (amino acid): 236
  • Reference: Hiniker et al. 2005; Pubmed- 16087673

    		• Similar resistance genes in 'BacMet Predicted database'
    fpvA
  • BacMet ID: BAC0169
  • Code for: Porin
  • Family: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga)
  • Description: Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membrane
  • Length (amino acid): 815
  • Reference: Hannauer et al. 2012; Pubmed- 22187978, Braud et al. 2009; Pubmed- 19207567

    		• Similar resistance genes in 'BacMet Predicted database'
    golT
  • BacMet ID: BAC0183
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Copper (Cu), Gold (Au)
  • Description: Cation transporting P-type ATPase; belongs to the gold-responsive, gol regulon; In the absence of CopA, GolS becomes responsive to copper, inducing the expression of golT, which functionally substitutes CopA for cytosolic copper export
  • Length (amino acid): 762
  • Reference: Espariz et al. 2007, Pubmed- 17768242

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0569
  • Code for: Regulator
  • Family: Contains response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Chromosome
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 129
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0190
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium medicae (strain WSM419) (Ensifer medicae), Plasmid pSymA (Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti))
  • Location: Plasmid pSMED01
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 147
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    hpcopA
  • BacMet ID: BAC0617
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in copper export.
  • Length (amino acid): 745
  • Reference: Ge et al. 1995; Pubmed- 7752900, Ge et al. 1996; Pubmed- 8961555

    		• Similar resistance genes in 'BacMet Predicted database'
    hpcopP
  • BacMet ID: BAC0618
  • Code for: Enzyme
  • Family: Contains Heavy-matal-associated (HMA) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the H.pylori cells.
  • Length (amino acid): 66
  • Reference: Ge et al. 1995; Pubmed- 7752900, Ge et al. 1996; Pubmed- 8961555

    		• Similar resistance genes in 'BacMet Predicted database'
    mco
  • BacMet ID: BAC0205
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co)
  • Description: Multicopper oxidase Mco; Involved in copper homeostasis and oxidative stress response. Oxidizes the substrate 3,3'-dimethoxybenzidine in vitro. Also possesses low levels of phenoloxidase and ferroxidase activities. A transposon-induced mutant showed copper and cobalt sensitivity and H2O2 tolerance.
  • Length (amino acid): 447
  • Reference: Sitthisak et al. 2005; Pubmed- 16151171

    		• Similar resistance genes in 'BacMet Predicted database'
    mctB
  • BacMet ID: BAC0206
  • Code for: Efflux
  • Family: MctB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Pore-forming protein MctB, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence.
  • Length (amino acid): 314
  • Reference: Wolschendorf et al. 2010; Pubmed- 21205886

    		• Similar resistance genes in 'BacMet Predicted database'
    mmco
  • BacMet ID: BAC0480
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Mmco is required for copper resistance in Mycobacterium tuberculosis. It acts by oxidation of toxic Cu(I) in the periplasm.
  • Length (amino acid): 504
  • Reference: Rowland et al. 2013; Pubmed- 23772064

    		• Similar resistance genes in 'BacMet Predicted database'
    mymT
  • BacMet ID: BAC0262
  • Code for: Binding protein
  • Family: Metallothionein superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu), Nickel (Ni), Zinc (Zn)
  • Description: Cu(I)-binding metallothionein mymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu+, with a preference for four to six Cu+ ions, in a solvent-shielded core. MymT protects M. tuberculosis from copper toxicity. Up-regulated by copper, cadmium, cobalt, nickel and zinc, but not manganese.
  • Length (amino acid): 53
  • Reference: Gold et al. 2011; Pubmed- 18724363, Festa et al. 2011; Pubmed- 21166899

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoA
  • BacMet ID: BAC0303
  • Code for: Enzyme
  • Family: Multi-copper oxidase family (CopA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein PcoA; required for the copper-inducible expression of copper resistance. May have oxidase activity; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 605
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoB
  • BacMet ID: BAC0304
  • Code for: Enzyme
  • Family: CopB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein PcoB; required for the copper-inducible expression of copper resistance; located in cell outer membrane; it's peripheral membrane protein
  • Length (amino acid): 296
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoC
  • BacMet ID: BAC0305
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein PcoC; required for the copper-inducible expression of copper resistance; located in periplasm; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 126
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoD
  • BacMet ID: BAC0306
  • Code for: Membrane Transporter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein D; Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 309
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoE
  • BacMet ID: BAC0307
  • Code for: Binding protein
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Copper-binding protein PcoE; lies distal, downstram from the regulatory genes (gene order in the operon- pcoABCDRSE); Required for the copper-inducible Expression of copper resistance. Activated by the two-component regulatory system CusS/CusR; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 144
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoR
  • BacMet ID: BAC0308
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Transcriptional regulatory protein PcoR; member of a two-component regulatory system pcoS/pcoR. Involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box). part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 226
  • Reference: Rouch & Brown. 1997; Pubmed- 9141682

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoS
  • BacMet ID: BAC0309
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Sensor protein PcoS; member of a two-component regulatory system PcoS/PcoR. Activate PcoR by phosphorylation; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 466
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pfr
  • BacMet ID: BAC0497
  • Code for: Binding protein
  • Family: Ferritin family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori
  • Location: Chromosome
  • Compound: Iron (Fe), Copper (Cu), Manganese (Mn)
  • Description: pfr gene encodes ferritin protein. Has role in iron metabolism of H. pylori. Binding and sequestration of metals by Pfr is not specific for iron. Iron resistance mediated by ferritin might be important for survival of the pathogen within its natural habitat, where it is faced with iron and other metals which originate from the diet.
  • Length (amino acid): 167
  • Reference: Bereswill et al. 1998; Pubmed- 9782498

    		• Similar resistance genes in 'BacMet Predicted database'
    ricR
  • BacMet ID: BAC0333
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis H37Rv
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper repressor ricR
  • Length (amino acid): 96
  • Reference: Festa et al. 2011; Pubmed- 21166899

    		• Similar resistance genes in 'BacMet Predicted database'
    tcrB
  • BacMet ID: BAC0383
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus faecium (Streptococcus faecium)
  • Location: Plasmid pA17sv1 (Enterococcus faecium),
  • Compound: Copper (Cu)
  • Description: The transferable, plasmid-localized Copper resistance efflux ATPase, TcrB
  • Length (amino acid): 710
  • Reference: Hasman te al. 2002; Pubmed- 11959576, Hasman et al. 2005; Pubmed- 16151212

    		• Similar resistance genes in 'BacMet Predicted database'
    trgB
  • BacMet ID: BAC0395
  • Code for: Enzyme
  • Family: Nudix hydrolase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacterales bacterium Y4I, Rhodobacter capsulatus
  • Location: Chromosome
  • Compound: Tellurium (Te), Copper (Cu)
  • Description: Tellurite resistance protein TrgB; Together with TrgA, it forms an operon
  • Length (amino acid): 361
  • Reference: O'Gara et al. 1997; Pubmed- 9406390, Rademacher et al. 2012; Pubmed- 22767205

    		• Similar resistance genes in 'BacMet Predicted database'
    ycnJ
  • BacMet ID: BAC0556
  • Code for: Membrane protein
  • Family: CopC and CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis168
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in uptake of extracellular oxidized copper under copper-limiting conditions. Highly induced under copper-limiting conditions. Down-regulated by YcnK, especially under high copper concentrations. Down-regulated by CsoR. Cells lacking this gene show a growth-defective phenotype under copper deprivation as well as a reduced intracellular content of copper.
  • Length (amino acid): 541
  • Reference: Chillappagari et al. 2009; Pubmed- 19168619

    		• Similar resistance genes in 'BacMet Predicted database'
    ycnK
  • BacMet ID: BAC0557
  • Code for: Regulator
  • Family: Contains 1 HTH deoR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis 168
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: May act as a negative transcriptional regulator of ycnJ in the presence of copper. May use copper as a corepressor. Significantly induced under copper-limiting conditions. Cells lacking this gene show little or no difference in growth under copper deprivation, whereas possessing enhanced growth under copper excess conditions. Possess a high intracellular content of copper.
  • Length (amino acid): 190
  • Reference: Chillappagari et al. 2009; Pubmed- 19168619

    		• Similar resistance genes in 'BacMet Predicted database'
    yfmO
  • BacMet ID: BAC0443
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168) 
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Multidrug efflux protein YfmO; Acts to efflux copper or a copper complex. YfmO can contribute to copper resistance; Repressed by YfmP
  • Length (amino acid): 396
  • Reference: Gaballa et al. 2003; Pubmed- 14663075

    		• Similar resistance genes in 'BacMet Predicted database'
    yfmP
  • BacMet ID: BAC0444
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subutilis (strain 168)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: HTH-type transcriptional regulator YfmP; repressor of the yfmOP operon. A mutation in yfmP leads to overexpression of yfmO, probably causing a decrease in cellular copper that is eventually responsible for a reduced copper induction of copZA. YfmP is autoregulated. There is no induction with copper or other metals.
  • Length (amino acid): 140
  • Reference: Gaballa et al. 2003; Pubmed- 14663075

    		• Similar resistance genes in 'BacMet Predicted database'
    zupT/ygiE
  • BacMet ID: BAC0469
  • Code for: Porter
  • Family: ZIP transporter family, ZupT subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd)
  • Description: Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.
  • Length (amino acid): 257
  • Reference: Grass et al. 2005; Pubmed- 15716430

    		• Similar resistance genes in 'BacMet Predicted database'
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